Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses
Joint Authors
Chang, Hsueh-Wei
Chuang, Li-Yeh
Lee, Yi-Chen
Moi, Sin-Hua
Hou, Ming-Feng
Yuan, Shyng Shiou
Yang, Cheng-Hong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The interaction between the meiotic recombination 11 homolog A (MRE11) oncoprotein and breast cancer recurrence status remains unclear.
The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer.
A dataset for 254 subjects with breast cancer (220 nonrecurrent and 34 recurrent) was used in individual and cumulated receiver operating characteristic (ROC) analyses of MRE11 and 12 clinicopathologic variables for predicting breast cancer recurrence.
In individual ROC analysis, the area under curve (AUC) for each predictor of breast cancer recurrence was smaller than 0.7.
In cumulated ROC analysis, however, the AUC value for each predictor improved.
Ten relevant variables in breast cancer recurrence were used to find the optimal prognostic indicators.
The presence of any six of the following ten variables had a high (79%) sensitivity and a high (70%) specificity for predicting breast cancer recurrence: tumor size ≥ 2.4 cm, tumor stage II/III, therapy other than hormone therapy, age ≥ 52 years, MRE11 positive cells > 50%, body mass index ≥ 24, lymph node metastasis, positivity for progesterone receptor, positivity for epidermal growth factor receptor, and negativity for estrogen receptor.
In conclusion, this study revealed that these 10 clinicopathologic variables are the minimum discriminators needed for optimal discriminant effectiveness in predicting breast cancer recurrence.
American Psychological Association (APA)
Yang, Cheng-Hong& Moi, Sin-Hua& Chuang, Li-Yeh& Yuan, Shyng Shiou& Hou, Ming-Feng& Lee, Yi-Chen…[et al.]. 2017. Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134907
Modern Language Association (MLA)
Yang, Cheng-Hong…[et al.]. Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134907
American Medical Association (AMA)
Yang, Cheng-Hong& Moi, Sin-Hua& Chuang, Li-Yeh& Yuan, Shyng Shiou& Hou, Ming-Feng& Lee, Yi-Chen…[et al.]. Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134907