Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma
المؤلفون المشاركون
Pan, Jiadong
Mei, Jie
Wang, Huiyu
Wang, Runjie
Liu, Chaoying
Xu, Juanying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The X-ray repair cross-complementing (XRCC) gene family has been revealed to participate in the carcinogenesis and development of numerous cancers.
However, the expression profiles and prognostic values of XRCCs (XRCC1-6) in hepatocellular carcinoma (HCC) have not been explored up to now.
The transcriptional levels of XRCCs in primary HCC tissues were analyzed by UALCAN and GEPIA.
The relationship between XRCCs expression and HCC clinical characteristics was evaluated using UALCAN.
Moreover, the prognostic values of XRCCs expression and mutations in HCC patients were investigated via the GEPIA and cBioPortal, respectively.
Last but not least, the functions and pathways of XRCCs in HCC were also predicted by cBioPortal and DVAID.
The transcriptional levels of all XRCCs in HCC tissues were notably elevated compared with normal liver tissues.
Meanwhile, upregulated XRCCs expression was positively associated with clinical stages and tumor grades of HCC patients.
Survival analysis using the GEPIA database revealed that high transcription levels of XRCC2/3/4/5/6 were associated with lower overall survival (OS) and high transcription levels of XRCC1/2/3/6 were correlated with poor disease-free survival (DFS) in HCC patients.
Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) demonstrated the possible mechanisms of XRCCs and their associated genes participating in the oncogenesis of HCC.
Our findings systematically elucidate the expression profiles and distinct prognostic values of XRCCs in HCC, which might provide promising therapeutic targets and novel prognostic biomarkers for HCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mei, Jie& Wang, Huiyu& Wang, Runjie& Pan, Jiadong& Liu, Chaoying& Xu, Juanying. 2020. Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134923
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mei, Jie…[et al.]. Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1134923
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mei, Jie& Wang, Huiyu& Wang, Runjie& Pan, Jiadong& Liu, Chaoying& Xu, Juanying. Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134923
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134923
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر