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Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma
Joint Authors
Pan, Jiadong
Mei, Jie
Wang, Huiyu
Wang, Runjie
Liu, Chaoying
Xu, Juanying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The X-ray repair cross-complementing (XRCC) gene family has been revealed to participate in the carcinogenesis and development of numerous cancers.
However, the expression profiles and prognostic values of XRCCs (XRCC1-6) in hepatocellular carcinoma (HCC) have not been explored up to now.
The transcriptional levels of XRCCs in primary HCC tissues were analyzed by UALCAN and GEPIA.
The relationship between XRCCs expression and HCC clinical characteristics was evaluated using UALCAN.
Moreover, the prognostic values of XRCCs expression and mutations in HCC patients were investigated via the GEPIA and cBioPortal, respectively.
Last but not least, the functions and pathways of XRCCs in HCC were also predicted by cBioPortal and DVAID.
The transcriptional levels of all XRCCs in HCC tissues were notably elevated compared with normal liver tissues.
Meanwhile, upregulated XRCCs expression was positively associated with clinical stages and tumor grades of HCC patients.
Survival analysis using the GEPIA database revealed that high transcription levels of XRCC2/3/4/5/6 were associated with lower overall survival (OS) and high transcription levels of XRCC1/2/3/6 were correlated with poor disease-free survival (DFS) in HCC patients.
Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) demonstrated the possible mechanisms of XRCCs and their associated genes participating in the oncogenesis of HCC.
Our findings systematically elucidate the expression profiles and distinct prognostic values of XRCCs in HCC, which might provide promising therapeutic targets and novel prognostic biomarkers for HCC patients.
American Psychological Association (APA)
Mei, Jie& Wang, Huiyu& Wang, Runjie& Pan, Jiadong& Liu, Chaoying& Xu, Juanying. 2020. Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134923
Modern Language Association (MLA)
Mei, Jie…[et al.]. Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1134923
American Medical Association (AMA)
Mei, Jie& Wang, Huiyu& Wang, Runjie& Pan, Jiadong& Liu, Chaoying& Xu, Juanying. Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134923