Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma
المؤلفون المشاركون
Jiang, Yaofei
Wang, Yibing
Li, Cong
Zou, Zhenhong
Liang, Bo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
With recent advances in immunooncology and tumor microenvironment, the treatment landscape of bladder urothelial carcinoma has been changing dramatically.
We aim to construct an immune gene-related signature which can predict BLCA patients’ overall survival.
Transcriptomic data of BLCA patients was downloaded from The Cancer Genome Atlas database, and immune-related genes were downloaded from the Immunology Database and Analysis Portal database.
Prognostic immune-related genes were identified.
We then constructed and validated an immune gene-related signature.
Tumor-related transcription factors were downloaded from the Cistrome database, and a network between them and prognostic immune-related genes was generated.
Cox’s proportional hazards model and the Kaplan–Meier survival analysis were performed to assess our signature’s prognostic ability.
Relationship between the signature and patients’ clinicopathologic features was then explored to validate its clinical value.
We further downloaded concentration of six types of immune cells from the Tumor Immune Estimation Resource database to explore immune-related potential mechanisms of the signature.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Yaofei& Wang, Yibing& Li, Cong& Zou, Zhenhong& Liang, Bo. 2020. Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Yaofei…[et al.]. Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1135019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Yaofei& Wang, Yibing& Li, Cong& Zou, Zhenhong& Liang, Bo. Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر