Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma
Joint Authors
Jiang, Yaofei
Wang, Yibing
Li, Cong
Zou, Zhenhong
Liang, Bo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
With recent advances in immunooncology and tumor microenvironment, the treatment landscape of bladder urothelial carcinoma has been changing dramatically.
We aim to construct an immune gene-related signature which can predict BLCA patients’ overall survival.
Transcriptomic data of BLCA patients was downloaded from The Cancer Genome Atlas database, and immune-related genes were downloaded from the Immunology Database and Analysis Portal database.
Prognostic immune-related genes were identified.
We then constructed and validated an immune gene-related signature.
Tumor-related transcription factors were downloaded from the Cistrome database, and a network between them and prognostic immune-related genes was generated.
Cox’s proportional hazards model and the Kaplan–Meier survival analysis were performed to assess our signature’s prognostic ability.
Relationship between the signature and patients’ clinicopathologic features was then explored to validate its clinical value.
We further downloaded concentration of six types of immune cells from the Tumor Immune Estimation Resource database to explore immune-related potential mechanisms of the signature.
American Psychological Association (APA)
Jiang, Yaofei& Wang, Yibing& Li, Cong& Zou, Zhenhong& Liang, Bo. 2020. Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135019
Modern Language Association (MLA)
Jiang, Yaofei…[et al.]. Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1135019
American Medical Association (AMA)
Jiang, Yaofei& Wang, Yibing& Li, Cong& Zou, Zhenhong& Liang, Bo. Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135019