D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis
المؤلفون المشاركون
Long, Hui
Nie, Lan
Xiang, Xiaochen
Li, Huan
Zhang, Xiaoli
Fu, Xiaozhi
Ren, Hongwei
Liu, Wanxin
Wang, Qiang
Wu, Qingming
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the value of coagulation indicators D-dimer (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (Fg) in predicting the severity and prognosis of COVID-19.
Methods.
A total of 115 patients with confirmed COVID-19, who were admitted to Tianyou Hospital of Wuhan University of Science and Technology between January 18, 2020, and March 5, 2020, were included.
The dynamic changes of DD, PT, APTT, and Fg were tested, and the correlation with CT imaging, clinical classifications, and prognosis was studied.
Results.
Coagulation disorder occurred at the early stage of COVID-19 infection, with 50 (43.5%) patients having DD increased and 74 (64.3%) patients having Fg increased.
The levels of DD and Fg were correlated with clinical classification.
Among 23 patients who deceased, 18 had DD increased at the first lab test, 22 had DD increased at the second and third lab tests, and 18 had prolonged PT at the third test.
The results from ROC analyses for mortality risk showed that the AUCs of DD were 0.742, 0.818, and 0.851 in three times of test, respectively; PT was 0.643, 0.824, and 0.937.
In addition, with the progression of the disease, the change of CT imaging was closely related to the increase of the DD value (P<0.01).
Conclusions.
Coagulation dysfunction is more likely to occur in severe and critically ill patients.
DD and PT could be used as the significant indicators in predicting the mortality of COVID-19.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Long, Hui& Nie, Lan& Xiang, Xiaochen& Li, Huan& Zhang, Xiaoli& Fu, Xiaozhi…[et al.]. 2020. D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135586
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Long, Hui…[et al.]. D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1135586
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Long, Hui& Nie, Lan& Xiang, Xiaochen& Li, Huan& Zhang, Xiaoli& Fu, Xiaozhi…[et al.]. D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135586
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135586
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر