D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis
Joint Authors
Long, Hui
Nie, Lan
Xiang, Xiaochen
Li, Huan
Zhang, Xiaoli
Fu, Xiaozhi
Ren, Hongwei
Liu, Wanxin
Wang, Qiang
Wu, Qingming
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate the value of coagulation indicators D-dimer (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (Fg) in predicting the severity and prognosis of COVID-19.
Methods.
A total of 115 patients with confirmed COVID-19, who were admitted to Tianyou Hospital of Wuhan University of Science and Technology between January 18, 2020, and March 5, 2020, were included.
The dynamic changes of DD, PT, APTT, and Fg were tested, and the correlation with CT imaging, clinical classifications, and prognosis was studied.
Results.
Coagulation disorder occurred at the early stage of COVID-19 infection, with 50 (43.5%) patients having DD increased and 74 (64.3%) patients having Fg increased.
The levels of DD and Fg were correlated with clinical classification.
Among 23 patients who deceased, 18 had DD increased at the first lab test, 22 had DD increased at the second and third lab tests, and 18 had prolonged PT at the third test.
The results from ROC analyses for mortality risk showed that the AUCs of DD were 0.742, 0.818, and 0.851 in three times of test, respectively; PT was 0.643, 0.824, and 0.937.
In addition, with the progression of the disease, the change of CT imaging was closely related to the increase of the DD value (P<0.01).
Conclusions.
Coagulation dysfunction is more likely to occur in severe and critically ill patients.
DD and PT could be used as the significant indicators in predicting the mortality of COVID-19.
American Psychological Association (APA)
Long, Hui& Nie, Lan& Xiang, Xiaochen& Li, Huan& Zhang, Xiaoli& Fu, Xiaozhi…[et al.]. 2020. D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135586
Modern Language Association (MLA)
Long, Hui…[et al.]. D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1135586
American Medical Association (AMA)
Long, Hui& Nie, Lan& Xiang, Xiaochen& Li, Huan& Zhang, Xiaoli& Fu, Xiaozhi…[et al.]. D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135586