Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature
المؤلفون المشاركون
Mobini, Narciss
Dhillon, Rummit
Dickey, Jason
Spoon, Jordan
Sadrolashrafi, Kaviyon
المصدر
Case Reports in Dermatological Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Recent emergence of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of cancers and produced prolonged response by boosting the immune system against tumor cells.
The primary target antigens are cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), a downregulator of T-cell activation, and programmed cell death-1 receptor (PD-1), a regulator of T-cell proliferation.
This enhanced immune response can induce autoimmune adverse effects in many organs.
Although skin toxicities are the most common, sarcoidal inflammation with exclusive cutaneous involvement is a rare occurrence with only 6 cases reported to date.
We report 2 cases with unusual features.
One patient is a female who was treated for metastatic renal cell carcinoma with combination of ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1).
She developed deep nodules showing sarcoidal dermatitis and panniculitis on histopathologic exam.
The second patient is a male with melanoma of eyelid conjunctiva who was treated prophylactically with ipilimumab.
He presented with papules/plaques confined to black tattoos, where the biopsy revealed sarcoidal dermatitis.
By a comprehensive literature review, we intend to raise awareness about this potential skin side effect in the growing number of patients receiving targeted immunotherapies.
It is crucial to have a high index of suspicion and perform timely biopsies to implement appropriate management strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mobini, Narciss& Dhillon, Rummit& Dickey, Jason& Spoon, Jordan& Sadrolashrafi, Kaviyon. 2019. Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature. Case Reports in Dermatological Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mobini, Narciss…[et al.]. Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature. Case Reports in Dermatological Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1135611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mobini, Narciss& Dhillon, Rummit& Dickey, Jason& Spoon, Jordan& Sadrolashrafi, Kaviyon. Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature. Case Reports in Dermatological Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر