Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature
Joint Authors
Mobini, Narciss
Dhillon, Rummit
Dickey, Jason
Spoon, Jordan
Sadrolashrafi, Kaviyon
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent emergence of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of cancers and produced prolonged response by boosting the immune system against tumor cells.
The primary target antigens are cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), a downregulator of T-cell activation, and programmed cell death-1 receptor (PD-1), a regulator of T-cell proliferation.
This enhanced immune response can induce autoimmune adverse effects in many organs.
Although skin toxicities are the most common, sarcoidal inflammation with exclusive cutaneous involvement is a rare occurrence with only 6 cases reported to date.
We report 2 cases with unusual features.
One patient is a female who was treated for metastatic renal cell carcinoma with combination of ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1).
She developed deep nodules showing sarcoidal dermatitis and panniculitis on histopathologic exam.
The second patient is a male with melanoma of eyelid conjunctiva who was treated prophylactically with ipilimumab.
He presented with papules/plaques confined to black tattoos, where the biopsy revealed sarcoidal dermatitis.
By a comprehensive literature review, we intend to raise awareness about this potential skin side effect in the growing number of patients receiving targeted immunotherapies.
It is crucial to have a high index of suspicion and perform timely biopsies to implement appropriate management strategies.
American Psychological Association (APA)
Mobini, Narciss& Dhillon, Rummit& Dickey, Jason& Spoon, Jordan& Sadrolashrafi, Kaviyon. 2019. Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature. Case Reports in Dermatological Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135611
Modern Language Association (MLA)
Mobini, Narciss…[et al.]. Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature. Case Reports in Dermatological Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1135611
American Medical Association (AMA)
Mobini, Narciss& Dhillon, Rummit& Dickey, Jason& Spoon, Jordan& Sadrolashrafi, Kaviyon. Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature. Case Reports in Dermatological Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135611