Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect
المؤلفون المشاركون
Guo, Qian-nan
Wang, Hong-dan
Tie, Li-zhen
Li, Tao
Xiao, Hai
Long, Jian-gang
Liao, Shi-xiu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Congenital heart defect (CHD) is one of the most common birth defects in the world.
The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD.
However, the correlations between the two genes and fetal CHD were inconsistent in various reports.
Therefore, this study is aimed to evaluate the parental effects of the two genes on fetal CHD via three genetic polymorphisms, MTHFR 677C>T (rs1801133), MTHFR 1298 A>C (rs1801131), and MTRR 66A>G (rs1801394).
Methods.
Parents with pregnancy history of fetal CHD were divided into two subgroups: ventricular septal defect (VSD) (21) and non-VSD groups (78).
VSD, non-VSD, and 114 control parents (controls) were analyzed in this study.
Genotyping of these genetic polymorphisms was done by sequencing.
Results.
The MTHFR 677C>T polymorphism of either mothers or fathers was independently associated with fetal non-VSD (P<0.05) but not VSD, while the MTRR 66A>G polymorphism was independently associated with fetal VSD (P<0.05) but not non-VSD.
No significance was found for MTHFR 1298A>C polymorphism.
Conclusion.
In either maternal or paternal group, the MTHFR 677C>T polymorphism was independently related to fetal non-VSD, while the MTRR 66A>G polymorphism was independently related to fetal VSD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Qian-nan& Wang, Hong-dan& Tie, Li-zhen& Li, Tao& Xiao, Hai& Long, Jian-gang…[et al.]. 2017. Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135653
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Qian-nan…[et al.]. Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135653
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Qian-nan& Wang, Hong-dan& Tie, Li-zhen& Li, Tao& Xiao, Hai& Long, Jian-gang…[et al.]. Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135653
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135653
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر