Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect
Joint Authors
Guo, Qian-nan
Wang, Hong-dan
Tie, Li-zhen
Li, Tao
Xiao, Hai
Long, Jian-gang
Liao, Shi-xiu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Congenital heart defect (CHD) is one of the most common birth defects in the world.
The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD.
However, the correlations between the two genes and fetal CHD were inconsistent in various reports.
Therefore, this study is aimed to evaluate the parental effects of the two genes on fetal CHD via three genetic polymorphisms, MTHFR 677C>T (rs1801133), MTHFR 1298 A>C (rs1801131), and MTRR 66A>G (rs1801394).
Methods.
Parents with pregnancy history of fetal CHD were divided into two subgroups: ventricular septal defect (VSD) (21) and non-VSD groups (78).
VSD, non-VSD, and 114 control parents (controls) were analyzed in this study.
Genotyping of these genetic polymorphisms was done by sequencing.
Results.
The MTHFR 677C>T polymorphism of either mothers or fathers was independently associated with fetal non-VSD (P<0.05) but not VSD, while the MTRR 66A>G polymorphism was independently associated with fetal VSD (P<0.05) but not non-VSD.
No significance was found for MTHFR 1298A>C polymorphism.
Conclusion.
In either maternal or paternal group, the MTHFR 677C>T polymorphism was independently related to fetal non-VSD, while the MTRR 66A>G polymorphism was independently related to fetal VSD.
American Psychological Association (APA)
Guo, Qian-nan& Wang, Hong-dan& Tie, Li-zhen& Li, Tao& Xiao, Hai& Long, Jian-gang…[et al.]. 2017. Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135653
Modern Language Association (MLA)
Guo, Qian-nan…[et al.]. Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135653
American Medical Association (AMA)
Guo, Qian-nan& Wang, Hong-dan& Tie, Li-zhen& Li, Tao& Xiao, Hai& Long, Jian-gang…[et al.]. Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135653