Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells
المؤلفون المشاركون
Yumoto, Hiromichi
Murakami, Keiji
Amoh, Takashi
Matsuo, Takashi
Miyake, Yoichiro
Hirao, Kouji
Susilowati, Heni
Hirota, Katsuhiko
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Pseudomonas aeruginosa is a Gram-negative bacterium and causes respiratory infection especially in elderly patients.
Royal jelly has been used worldwide as a traditional remedy and as a nutrient; however, the effect against P.
aeruginosa is unclear.
The aim of this study was to analyze antibacterial, antiadherent, and anti-inflammatory effects of royal jelly against P.
aeruginosa.
Wild-type strain PAO1 and clinical isolates of P.
aeruginosa were used for antibacterial assay and antiadherent assay to abiotic surface and epithelial cells, which are pharynx (Detroit 562) and lung (NCI-H292) epithelial cells.
In anti-inflammatory assay, epithelial cells were pretreated with royal jelly before bacterial exposure to investigate its inhibitory effect on interleukin (IL-8) and macrophage inflammatory protein-3α/CCL20 overproduction.
Although royal jelly did not have antibacterial activity at concentration of 50% w/v, antiadherent activity was confirmed on the abiotic surface and epithelial cells under concentration of 25%.
Pretreatment with royal jelly significantly inhibited overproduction of IL-8 and CCL20 from both cells.
These results demonstrated that royal jelly inhibits P.
aeruginosa adherence and protects epithelial cells from excessive inflammatory responses against P.
aeruginosa infection.
Our findings suggested that royal jelly may be a useful supplement as complementary and alternative medicine for preventing respiratory infection caused by P.
aeruginosa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Susilowati, Heni& Murakami, Keiji& Yumoto, Hiromichi& Amoh, Takashi& Hirao, Kouji& Hirota, Katsuhiko…[et al.]. 2017. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Susilowati, Heni…[et al.]. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1135825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Susilowati, Heni& Murakami, Keiji& Yumoto, Hiromichi& Amoh, Takashi& Hirao, Kouji& Hirota, Katsuhiko…[et al.]. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135825
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر