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Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells
Joint Authors
Yumoto, Hiromichi
Murakami, Keiji
Amoh, Takashi
Matsuo, Takashi
Miyake, Yoichiro
Hirao, Kouji
Susilowati, Heni
Hirota, Katsuhiko
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pseudomonas aeruginosa is a Gram-negative bacterium and causes respiratory infection especially in elderly patients.
Royal jelly has been used worldwide as a traditional remedy and as a nutrient; however, the effect against P.
aeruginosa is unclear.
The aim of this study was to analyze antibacterial, antiadherent, and anti-inflammatory effects of royal jelly against P.
aeruginosa.
Wild-type strain PAO1 and clinical isolates of P.
aeruginosa were used for antibacterial assay and antiadherent assay to abiotic surface and epithelial cells, which are pharynx (Detroit 562) and lung (NCI-H292) epithelial cells.
In anti-inflammatory assay, epithelial cells were pretreated with royal jelly before bacterial exposure to investigate its inhibitory effect on interleukin (IL-8) and macrophage inflammatory protein-3α/CCL20 overproduction.
Although royal jelly did not have antibacterial activity at concentration of 50% w/v, antiadherent activity was confirmed on the abiotic surface and epithelial cells under concentration of 25%.
Pretreatment with royal jelly significantly inhibited overproduction of IL-8 and CCL20 from both cells.
These results demonstrated that royal jelly inhibits P.
aeruginosa adherence and protects epithelial cells from excessive inflammatory responses against P.
aeruginosa infection.
Our findings suggested that royal jelly may be a useful supplement as complementary and alternative medicine for preventing respiratory infection caused by P.
aeruginosa.
American Psychological Association (APA)
Susilowati, Heni& Murakami, Keiji& Yumoto, Hiromichi& Amoh, Takashi& Hirao, Kouji& Hirota, Katsuhiko…[et al.]. 2017. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135825
Modern Language Association (MLA)
Susilowati, Heni…[et al.]. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1135825
American Medical Association (AMA)
Susilowati, Heni& Murakami, Keiji& Yumoto, Hiromichi& Amoh, Takashi& Hirao, Kouji& Hirota, Katsuhiko…[et al.]. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135825