![](/images/graphics-bg.png)
Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases
المؤلفون المشاركون
Hiura, Akio
Nakagawa, Hiroshi
Kusaka, Shunji
Shimomura, Yoshikazu
Eguchi, Hiroshi
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-07
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Recently, in vivo confocal microscopy is used to examine the human corneal nerve fibers morphology.
Corneal nerve fiber architecture and its role are studied in healthy and pathological conditions.
Corneal nerves of rats were studied by nonspecific acetylcholinesterase (NsAchE) staining.
NsAchE-positive subepithelial (stromal) nerve fiber has been found to be insensitive to capsaicin.
Besides, NsAchE-negative but capsaicin-sensitive subbasal nerve (leash) fibers formed thick mesh-like structure showing close interconnections and exhibit both isolectin B4- and transient receptor potential vanilloid channel 1- (TRPV1-) positive.
TRPV1, TRPV3, TRPA (ankyrin) 1, and TRPM (melastatin) 8 are expressed in corneal nerve fibers.
Besides the corneal nerve fibers, the expressions of TRPV (1, 3, and 4), TRPC (canonical) 4, and TRPM8 are demonstrated in the corneal epithelial cell membrane.
The realization of the importance of TRP channels acting as polymodal sensors of environmental stresses has identified potential drug targets for corneal disease.
The pathophysiological conditions of corneal diseases are associated with disruption of normal tissue innervation, especially capsaicin-sensitive small sensory nerve fibers.
The relationships between subbasal corneal nerve fiber morphology and neurotrophic keratopathy in corneal diseases are well studied.
The recommended treatment for neurotrophic keratopathy is administration of preservative free eye drops.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eguchi, Hiroshi& Hiura, Akio& Nakagawa, Hiroshi& Kusaka, Shunji& Shimomura, Yoshikazu. 2017. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. BioMed Research International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1135860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eguchi, Hiroshi…[et al.]. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. BioMed Research International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1135860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eguchi, Hiroshi& Hiura, Akio& Nakagawa, Hiroshi& Kusaka, Shunji& Shimomura, Yoshikazu. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1135860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)