Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases
Joint Authors
Hiura, Akio
Nakagawa, Hiroshi
Kusaka, Shunji
Shimomura, Yoshikazu
Eguchi, Hiroshi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Recently, in vivo confocal microscopy is used to examine the human corneal nerve fibers morphology.
Corneal nerve fiber architecture and its role are studied in healthy and pathological conditions.
Corneal nerves of rats were studied by nonspecific acetylcholinesterase (NsAchE) staining.
NsAchE-positive subepithelial (stromal) nerve fiber has been found to be insensitive to capsaicin.
Besides, NsAchE-negative but capsaicin-sensitive subbasal nerve (leash) fibers formed thick mesh-like structure showing close interconnections and exhibit both isolectin B4- and transient receptor potential vanilloid channel 1- (TRPV1-) positive.
TRPV1, TRPV3, TRPA (ankyrin) 1, and TRPM (melastatin) 8 are expressed in corneal nerve fibers.
Besides the corneal nerve fibers, the expressions of TRPV (1, 3, and 4), TRPC (canonical) 4, and TRPM8 are demonstrated in the corneal epithelial cell membrane.
The realization of the importance of TRP channels acting as polymodal sensors of environmental stresses has identified potential drug targets for corneal disease.
The pathophysiological conditions of corneal diseases are associated with disruption of normal tissue innervation, especially capsaicin-sensitive small sensory nerve fibers.
The relationships between subbasal corneal nerve fiber morphology and neurotrophic keratopathy in corneal diseases are well studied.
The recommended treatment for neurotrophic keratopathy is administration of preservative free eye drops.
American Psychological Association (APA)
Eguchi, Hiroshi& Hiura, Akio& Nakagawa, Hiroshi& Kusaka, Shunji& Shimomura, Yoshikazu. 2017. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. BioMed Research International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1135860
Modern Language Association (MLA)
Eguchi, Hiroshi…[et al.]. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. BioMed Research International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1135860
American Medical Association (AMA)
Eguchi, Hiroshi& Hiura, Akio& Nakagawa, Hiroshi& Kusaka, Shunji& Shimomura, Yoshikazu. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1135860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135860