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Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction
المؤلفون المشاركون
Zhai, Jianying
Ai-Ming, Wu
Gao, Yonghong
Shang, Hongcai
Hai-Yan, Zhu
Zhao, Mingjing
Chai, Limin
Li-Xia, Lou
Zhang, Dong-mei
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia.
Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions.
The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI.
Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups.
The MI rat model was created by coronary artery ligation.
Treatments were administrated intragastrically to the rats for 4 weeks.
Conventional transmission electron microscopy was performed to observe the ultrastructure of gap junctions.
Quantitative real-time PCR and western blotting were used to detect the expression of miR-1, protein kinase C (PKC), and related proteins.
Additionally, a programmatic electrophysiological stimulation test was performed to detect the ventricular fibrillation threshold (VFT).
WXKL protected the ultrastructure of the gap junctions and their constituent Cx43 by regulating miR-1 and PKC mediated signal transduction and increased the VFT significantly in the rat MI model.
The results suggested that WXKL is an effective alternative medicine to prevent potentially lethal arrhythmia following MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ai-Ming, Wu& Zhao, Mingjing& Li-Xia, Lou& Zhai, Jianying& Zhang, Dong-mei& Hai-Yan, Zhu…[et al.]. 2017. Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ai-Ming, Wu…[et al.]. Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1136005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ai-Ming, Wu& Zhao, Mingjing& Li-Xia, Lou& Zhai, Jianying& Zhang, Dong-mei& Hai-Yan, Zhu…[et al.]. Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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