Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction
Joint Authors
Zhai, Jianying
Ai-Ming, Wu
Gao, Yonghong
Shang, Hongcai
Hai-Yan, Zhu
Zhao, Mingjing
Chai, Limin
Li-Xia, Lou
Zhang, Dong-mei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia.
Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions.
The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI.
Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups.
The MI rat model was created by coronary artery ligation.
Treatments were administrated intragastrically to the rats for 4 weeks.
Conventional transmission electron microscopy was performed to observe the ultrastructure of gap junctions.
Quantitative real-time PCR and western blotting were used to detect the expression of miR-1, protein kinase C (PKC), and related proteins.
Additionally, a programmatic electrophysiological stimulation test was performed to detect the ventricular fibrillation threshold (VFT).
WXKL protected the ultrastructure of the gap junctions and their constituent Cx43 by regulating miR-1 and PKC mediated signal transduction and increased the VFT significantly in the rat MI model.
The results suggested that WXKL is an effective alternative medicine to prevent potentially lethal arrhythmia following MI.
American Psychological Association (APA)
Ai-Ming, Wu& Zhao, Mingjing& Li-Xia, Lou& Zhai, Jianying& Zhang, Dong-mei& Hai-Yan, Zhu…[et al.]. 2017. Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136005
Modern Language Association (MLA)
Ai-Ming, Wu…[et al.]. Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1136005
American Medical Association (AMA)
Ai-Ming, Wu& Zhao, Mingjing& Li-Xia, Lou& Zhai, Jianying& Zhang, Dong-mei& Hai-Yan, Zhu…[et al.]. Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1136005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136005