A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model
المؤلفون المشاركون
Friedman, Michael
Feldman, Mark
Shenderovich, Julia
Lavy, Eran
Steinberg, Doron
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Thiazolidinediones (TZDs) have been found to act as effective quorum sensing quenchers, capable of preventing biofilm formation.
Our previous studies demonstrated a profound antibiofilm effect of the TZD derivative thiazolidinedione-8 (S-8), either in solution or incorporated into a sustained-release membrane (SRM-S-8) under batch conditions.
In the present study, we used a constant depth film fermenter model in order to investigate the impact of SRM-S-8 on mixed C.
albicans-S.
mutans biofilm development, under flow conditions.
We found that essential parameters of cospecies biofilm maintenance and maturation, such as metabolic activity, biofilm thickness, roughness, extracellular polysaccharides production, and morphology of both pathogens, were altered by SRM-S-8 in the flow system.
We propose that prolonged and sustained release of S-8 in a flow-through system allows better penetration of the active agent to deeper layers of the mixed biofilm, thereby increasing its activity against both pathogens.
In conclusion, the use of a locally applied sustained-release drug delivery system of S-8 can affect the dental polymicrobial biofilm, resulting in clinical improvements and a better patient compliance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feldman, Mark& Shenderovich, Julia& Lavy, Eran& Friedman, Michael& Steinberg, Doron. 2017. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feldman, Mark…[et al.]. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feldman, Mark& Shenderovich, Julia& Lavy, Eran& Friedman, Michael& Steinberg, Doron. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر