A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model
Joint Authors
Friedman, Michael
Feldman, Mark
Shenderovich, Julia
Lavy, Eran
Steinberg, Doron
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Thiazolidinediones (TZDs) have been found to act as effective quorum sensing quenchers, capable of preventing biofilm formation.
Our previous studies demonstrated a profound antibiofilm effect of the TZD derivative thiazolidinedione-8 (S-8), either in solution or incorporated into a sustained-release membrane (SRM-S-8) under batch conditions.
In the present study, we used a constant depth film fermenter model in order to investigate the impact of SRM-S-8 on mixed C.
albicans-S.
mutans biofilm development, under flow conditions.
We found that essential parameters of cospecies biofilm maintenance and maturation, such as metabolic activity, biofilm thickness, roughness, extracellular polysaccharides production, and morphology of both pathogens, were altered by SRM-S-8 in the flow system.
We propose that prolonged and sustained release of S-8 in a flow-through system allows better penetration of the active agent to deeper layers of the mixed biofilm, thereby increasing its activity against both pathogens.
In conclusion, the use of a locally applied sustained-release drug delivery system of S-8 can affect the dental polymicrobial biofilm, resulting in clinical improvements and a better patient compliance.
American Psychological Association (APA)
Feldman, Mark& Shenderovich, Julia& Lavy, Eran& Friedman, Michael& Steinberg, Doron. 2017. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136032
Modern Language Association (MLA)
Feldman, Mark…[et al.]. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136032
American Medical Association (AMA)
Feldman, Mark& Shenderovich, Julia& Lavy, Eran& Friedman, Michael& Steinberg, Doron. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a CandidaBacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136032