Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits
المؤلفون المشاركون
Rodríguez-Castelán, Julia
Castelán, Francisco
Cuevas, Estela
Méndez-Tepepa, M.
Carrillo-Portillo, Y.
Anaya-Hernández, A.
Rodríguez-Antolín, J.
Zambrano, E.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Ovarian failure is related to dyslipidemias and inflammation, as well as to hypertrophy and dysfunction of the visceral adipose tissue (VAT).
Although hypothyroidism has been associated with obesity, dyslipidemias, and inflammation in humans and animals, its influence on the characteristics of ovarian follicles in adulthood is scarcely known.
Control and hypothyroid rabbits were used to analyze the ovarian follicles, expression of aromatase in the ovary, serum concentration of lipids, leptin, and uric acid, size of adipocytes, and infiltration of macrophages in the periovarian VAT.
Hypothyroidism did not affect the percentage of functional or atretic follicles.
However, it reduced the size of primary, secondary, and tertiary follicles considered as large and the expression of aromatase in the ovary.
This effect was associated with high serum concentrations of total cholesterol and low-density lipoprotein cholesterol (LDL-C).
In addition, hypothyroidism induced hypertrophy of adipocytes and a major infiltration of CD68+ macrophages into the periovarian VAT.
Our results suggest that the reduced size of ovarian follicles promoted by hypothyroidism could be associated with dyslipidemias, hypertrophy, and inflammation of the periovarian VAT.
Present findings may be useful to understand the influence of hypothyroidism in the ovary function in adulthood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodríguez-Castelán, Julia& Méndez-Tepepa, M.& Carrillo-Portillo, Y.& Anaya-Hernández, A.& Rodríguez-Antolín, J.& Zambrano, E.…[et al.]. 2017. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodríguez-Castelán, Julia…[et al.]. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1136396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodríguez-Castelán, Julia& Méndez-Tepepa, M.& Carrillo-Portillo, Y.& Anaya-Hernández, A.& Rodríguez-Antolín, J.& Zambrano, E.…[et al.]. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر