Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits
Joint Authors
Rodríguez-Castelán, Julia
Castelán, Francisco
Cuevas, Estela
Méndez-Tepepa, M.
Carrillo-Portillo, Y.
Anaya-Hernández, A.
Rodríguez-Antolín, J.
Zambrano, E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ovarian failure is related to dyslipidemias and inflammation, as well as to hypertrophy and dysfunction of the visceral adipose tissue (VAT).
Although hypothyroidism has been associated with obesity, dyslipidemias, and inflammation in humans and animals, its influence on the characteristics of ovarian follicles in adulthood is scarcely known.
Control and hypothyroid rabbits were used to analyze the ovarian follicles, expression of aromatase in the ovary, serum concentration of lipids, leptin, and uric acid, size of adipocytes, and infiltration of macrophages in the periovarian VAT.
Hypothyroidism did not affect the percentage of functional or atretic follicles.
However, it reduced the size of primary, secondary, and tertiary follicles considered as large and the expression of aromatase in the ovary.
This effect was associated with high serum concentrations of total cholesterol and low-density lipoprotein cholesterol (LDL-C).
In addition, hypothyroidism induced hypertrophy of adipocytes and a major infiltration of CD68+ macrophages into the periovarian VAT.
Our results suggest that the reduced size of ovarian follicles promoted by hypothyroidism could be associated with dyslipidemias, hypertrophy, and inflammation of the periovarian VAT.
Present findings may be useful to understand the influence of hypothyroidism in the ovary function in adulthood.
American Psychological Association (APA)
Rodríguez-Castelán, Julia& Méndez-Tepepa, M.& Carrillo-Portillo, Y.& Anaya-Hernández, A.& Rodríguez-Antolín, J.& Zambrano, E.…[et al.]. 2017. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136396
Modern Language Association (MLA)
Rodríguez-Castelán, Julia…[et al.]. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1136396
American Medical Association (AMA)
Rodríguez-Castelán, Julia& Méndez-Tepepa, M.& Carrillo-Portillo, Y.& Anaya-Hernández, A.& Rodríguez-Antolín, J.& Zambrano, E.…[et al.]. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136396