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From Human Mesenchymal Stem Cells to Insulin-Producing Cells: Comparison between Bone Marrow- and Adipose Tissue-Derived Cells
المؤلفون المشاركون
Ghoneim, Mohamed A.
Khater, Sherry M.
Abdel-Rahman, Engy A.
Ali, Sameh S.
Reda, Asmaa M.
Ismail, Hossam El-Din A.
Ashamallah, Sylvia A.
Ismail, Amani M.
Gabr, Mahmoud M.
Zakaria, Mahmoud M.
El-Badri, Nagwa
Refaie, Ayman F.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study is to compare human bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose tissue-derived mesenchymal stem cells (AT-MSCs), for their differentiation potentials to form insulin-producing cells.
BM-MSCs were obtained during elective orthotopic surgery and AT-MSCs from fatty aspirates during elective cosmetics procedures.
Following their expansion, cells were characterized by phenotyping, trilineage differentiation ability, and basal gene expression of pluripotency genes and for their metabolic characteristics.
Cells were differentiated according to a Trichostatin-A based protocol.
The differentiated cells were evaluated by immunocytochemistry staining for insulin and c-peptide.
In addition the expression of relevant pancreatic endocrine genes was determined.
The release of insulin and c-peptide in response to a glucose challenge was also quantitated.
There were some differences in basal gene expression and metabolic characteristics.
After differentiation the proportion of the resulting insulin-producing cells (IPCs), was comparable among both cell sources.
Again, there were no differences neither in the levels of gene expression nor in the amounts of insulin and c-peptide release as a function of glucose challenge.
The properties, availability, and abundance of AT-MSCs render them well-suited for applications in regenerative medicine.
Conclusion.
BM-MSCs and AT-MSCs are comparable regarding their differential potential to form IPCs.
The availability and properties of AT-MSCs render them well-suited for applications in regenerative medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gabr, Mahmoud M.& Zakaria, Mahmoud M.& Refaie, Ayman F.& Abdel-Rahman, Engy A.& Reda, Asmaa M.& Ali, Sameh S.…[et al.]. 2017. From Human Mesenchymal Stem Cells to Insulin-Producing Cells: Comparison between Bone Marrow- and Adipose Tissue-Derived Cells. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gabr, Mahmoud M.…[et al.]. From Human Mesenchymal Stem Cells to Insulin-Producing Cells: Comparison between Bone Marrow- and Adipose Tissue-Derived Cells. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gabr, Mahmoud M.& Zakaria, Mahmoud M.& Refaie, Ayman F.& Abdel-Rahman, Engy A.& Reda, Asmaa M.& Ali, Sameh S.…[et al.]. From Human Mesenchymal Stem Cells to Insulin-Producing Cells: Comparison between Bone Marrow- and Adipose Tissue-Derived Cells. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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