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The Use of Xanthan Gum as Vaccine Adjuvant: An Evaluation of Immunostimulatory Potential in BALBc Mice and Cytotoxicity In Vitro
المؤلفون المشاركون
Hartwig, Daiane D.
Oliveira, Thaís Larré
Collares, Thaís Farias
Monte, Leonardo Garcia
Inda, Guilherme Roig
Vendrusculo, Claire T.
Schuch, Rodrigo
Dellagostin, Odir A.
Moreira, Angelita da S.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The successful production of new, safe, and effective vaccines that generate immunological memory is directly related to adjuvant feature, which is responsible for increasing and/or modulating the immune response.
Several compounds display adjuvant activity, including carbohydrates.
These compounds play important roles in the immune response, as well as having biocompatible properties in vaccine formulations.
One such carbohydrate is xanthan gum, a polysaccharide that is produced by the plant-pathogenic bacterium Xanthomonas spp., which has adjuvant attributes.
This study evaluated the immune response induced by xanthan gum associated with ovalbumin in BALB/c mice, which were subcutaneously immunized, in terms of antibody production (IgG1, IgG2a, IgG2b, and IgG3), and assessed the levels of IFN-γ in the splenocyte culture using indirect ELISA.
Furthermore, we investigated in vitro cytotoxicity of xanthan in the embryo fibroblasts cell line of the NIH/3T3 mouse by MTT assay and propidium iodide uptake assay.
The mice immunized with ovalbumin plus xanthan gum exhibited higher antibody IgG1 responses than control groups.
Furthermore, the xanthan polysaccharide was capable of increasing the immunogenicity of antigens by producing IFN-γ and did not exhibit cytotoxicity effects in NIH/3T3 mouse fibroblast cells, considered a promising candidate for vaccine adjuvant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schuch, Rodrigo& Oliveira, Thaís Larré& Collares, Thaís Farias& Monte, Leonardo Garcia& Inda, Guilherme Roig& Dellagostin, Odir A.…[et al.]. 2017. The Use of Xanthan Gum as Vaccine Adjuvant: An Evaluation of Immunostimulatory Potential in BALBc Mice and Cytotoxicity In Vitro. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schuch, Rodrigo…[et al.]. The Use of Xanthan Gum as Vaccine Adjuvant: An Evaluation of Immunostimulatory Potential in BALBc Mice and Cytotoxicity In Vitro. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schuch, Rodrigo& Oliveira, Thaís Larré& Collares, Thaís Farias& Monte, Leonardo Garcia& Inda, Guilherme Roig& Dellagostin, Odir A.…[et al.]. The Use of Xanthan Gum as Vaccine Adjuvant: An Evaluation of Immunostimulatory Potential in BALBc Mice and Cytotoxicity In Vitro. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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