Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study
المؤلفون المشاركون
Li, Sheng
Yu, Dong-Hu
Liu, Xiao-Ping
Song, Cong-kuan
Guo, Zi-xin
Shen, Xiao-yan
Wang, Yu-jin
Wang, Qing-wen
Chen, Chen
Huang, Jing-yu
Hu, Weidong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
As a special type of lung cancer, multiple primary lung cancer (MPLC) has unique biological characteristics, and its research remains limited.
The aim of our research was to identify prognostic factors and construct a prognostic nomogram of dual primary lung cancer (DPLC).
A population cohort study of patients with DPLC was conducted using the extracted data from the Surveillance, Epidemiology, and End Results (SEER) database.
Relevant survival variables were identified using the Cox proportional hazard model.
Prognostic nomogram was performed and its predictive performance was validated via the modeling and validating cohort data.
Additionally, propensity score matching (PSM) was also applied to evaluate whether surgery affected the OS of this study population.
5411 eligible DPLC patients were included in this study cohort, with 41.0% of 3-year OS rate and 27.7% of 5-year OS rate.
Age, sex, race, grade, stage, lymph node (LN) metastasis, histological type, primary site, and surgery were considered to be prognostic factors of OS.
The C-indexes of the established nomogram were 0.70 (95% CI (0.69, 0.71)) in the modeling group and 0.70 (95% CI (0.68, 0.72)) in the validation group, which showed an ideal model discrimination ability.
AUC and calibration plots of 3- and 5-year OS also proved the good performance of the established nomogram.
After 1 : 1 PSM, surgery can potentially reduce the risk of OS (HR = 0.63, 95% CI: 0.56–0.72) of DPLC.
The prognostic nomogram with reliable performance was developed to predict 3- and 5-year OS rates, which could assist clinicians to make more reasonable survival prediction for DPLC patients.
For patients without absolute surgical contraindications, surgery should be actively considered.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Cong-kuan& Guo, Zi-xin& Shen, Xiao-yan& Wang, Yu-jin& Wang, Qing-wen& Yu, Dong-Hu…[et al.]. 2020. Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136643
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Cong-kuan…[et al.]. Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1136643
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Cong-kuan& Guo, Zi-xin& Shen, Xiao-yan& Wang, Yu-jin& Wang, Qing-wen& Yu, Dong-Hu…[et al.]. Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136643
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136643
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر