Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study
Joint Authors
Li, Sheng
Yu, Dong-Hu
Liu, Xiao-Ping
Song, Cong-kuan
Guo, Zi-xin
Shen, Xiao-yan
Wang, Yu-jin
Wang, Qing-wen
Chen, Chen
Huang, Jing-yu
Hu, Weidong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
As a special type of lung cancer, multiple primary lung cancer (MPLC) has unique biological characteristics, and its research remains limited.
The aim of our research was to identify prognostic factors and construct a prognostic nomogram of dual primary lung cancer (DPLC).
A population cohort study of patients with DPLC was conducted using the extracted data from the Surveillance, Epidemiology, and End Results (SEER) database.
Relevant survival variables were identified using the Cox proportional hazard model.
Prognostic nomogram was performed and its predictive performance was validated via the modeling and validating cohort data.
Additionally, propensity score matching (PSM) was also applied to evaluate whether surgery affected the OS of this study population.
5411 eligible DPLC patients were included in this study cohort, with 41.0% of 3-year OS rate and 27.7% of 5-year OS rate.
Age, sex, race, grade, stage, lymph node (LN) metastasis, histological type, primary site, and surgery were considered to be prognostic factors of OS.
The C-indexes of the established nomogram were 0.70 (95% CI (0.69, 0.71)) in the modeling group and 0.70 (95% CI (0.68, 0.72)) in the validation group, which showed an ideal model discrimination ability.
AUC and calibration plots of 3- and 5-year OS also proved the good performance of the established nomogram.
After 1 : 1 PSM, surgery can potentially reduce the risk of OS (HR = 0.63, 95% CI: 0.56–0.72) of DPLC.
The prognostic nomogram with reliable performance was developed to predict 3- and 5-year OS rates, which could assist clinicians to make more reasonable survival prediction for DPLC patients.
For patients without absolute surgical contraindications, surgery should be actively considered.
American Psychological Association (APA)
Song, Cong-kuan& Guo, Zi-xin& Shen, Xiao-yan& Wang, Yu-jin& Wang, Qing-wen& Yu, Dong-Hu…[et al.]. 2020. Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136643
Modern Language Association (MLA)
Song, Cong-kuan…[et al.]. Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1136643
American Medical Association (AMA)
Song, Cong-kuan& Guo, Zi-xin& Shen, Xiao-yan& Wang, Yu-jin& Wang, Qing-wen& Yu, Dong-Hu…[et al.]. Prognostic Factors Analysis and Nomogram Construction of Dual Primary Lung Cancer: A Population Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136643