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General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies
المؤلفون المشاركون
Luo, Ai-Lin
Tang, Xiaole
Zhao, Yilin
Zhou, Zhiqiang
Yan, Jing
Li, Shiyong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
General anesthetic (GA) is used clinically to millions of young children each year to facilitate surgical procedures, relieve perioperative stress, and provide analgesia and amnesia.
During recent years, there is a growing concern regarding a causal association between early life GA exposure and subsequently long-term neurocognitive abnormalities.
To address the increasing concern, mounting preclinical studies and clinical trials have been undergoing.
Until now, nearly all of the preclinical findings show that neonatal exposure to GA causally leads to acute neural cell injury and delayed cognitive impairment.
Unexpectedly, several influential clinical findings suggest that early life GA exposure, especially brief and single exposure, does not cause adverse neurodevelopmental outcome, which is not fully in line with the experimental findings and data from several previous cohort trials.
As the clinical data have been critically discussed in previous reviews, in the present review, we try to analyze the potential factors of the experimental studies that may overestimate the adverse effect of GA on the developing brain.
Meanwhile, we briefly summarized the advance in experimental research.
Generally, our purpose is to provide some useful suggestions for forthcoming preclinical studies and strengthen the powerfulness of preclinical data.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Ai-Lin& Tang, Xiaole& Zhao, Yilin& Zhou, Zhiqiang& Yan, Jing& Li, Shiyong. 2020. General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Ai-Lin…[et al.]. General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Ai-Lin& Tang, Xiaole& Zhao, Yilin& Zhou, Zhiqiang& Yan, Jing& Li, Shiyong. General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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