General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies
Joint Authors
Luo, Ai-Lin
Tang, Xiaole
Zhao, Yilin
Zhou, Zhiqiang
Yan, Jing
Li, Shiyong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
General anesthetic (GA) is used clinically to millions of young children each year to facilitate surgical procedures, relieve perioperative stress, and provide analgesia and amnesia.
During recent years, there is a growing concern regarding a causal association between early life GA exposure and subsequently long-term neurocognitive abnormalities.
To address the increasing concern, mounting preclinical studies and clinical trials have been undergoing.
Until now, nearly all of the preclinical findings show that neonatal exposure to GA causally leads to acute neural cell injury and delayed cognitive impairment.
Unexpectedly, several influential clinical findings suggest that early life GA exposure, especially brief and single exposure, does not cause adverse neurodevelopmental outcome, which is not fully in line with the experimental findings and data from several previous cohort trials.
As the clinical data have been critically discussed in previous reviews, in the present review, we try to analyze the potential factors of the experimental studies that may overestimate the adverse effect of GA on the developing brain.
Meanwhile, we briefly summarized the advance in experimental research.
Generally, our purpose is to provide some useful suggestions for forthcoming preclinical studies and strengthen the powerfulness of preclinical data.
American Psychological Association (APA)
Luo, Ai-Lin& Tang, Xiaole& Zhao, Yilin& Zhou, Zhiqiang& Yan, Jing& Li, Shiyong. 2020. General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136807
Modern Language Association (MLA)
Luo, Ai-Lin…[et al.]. General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136807
American Medical Association (AMA)
Luo, Ai-Lin& Tang, Xiaole& Zhao, Yilin& Zhou, Zhiqiang& Yan, Jing& Li, Shiyong. General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136807