Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B
المؤلفون المشاركون
Roytrakul, Sittiruk
Jittorntam, Paisan
Petraksa, Supanna
Sobhonslidsuk, Abhasnee
Wanichanuwat, Jirachaya
Numthavaj, Pawin
Sophonsritsuk, Areepan
Pugasub, Alongkorn
Kongsomgan, Anucha
Phakdeekitcharoen, Bunyong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
Proximal renal tubular dysfunction (PRTD) is an infrequent complication after nucleotide analogue therapy.
We evaluated the outcomes of PRTD and nephrotoxicity after nucleotide analogue withdrawal in chronic hepatitis B (CHB).
Methods.
A longitudinal follow-up study was performed in patients with PRTD after nucleotide analogue discontinuation.
Serum and urine were collected at baseline and every 3 months for one year.
The fractional excretion of phosphate (PO4), uric acid (UA), and potassium and tubular maximal reabsorption rate of PO4 to glomerular filtration rate (TmPO4/GFR) were calculated.
Renal losses were defined based on the criteria of substance losses.
Subclinical PRTD and overt PRTD were diagnosed when 2 and ≥3 criteria were identified.
Results.
Eight subclinical and eight overt PRTD patients were enrolled.
After nucleotide analogue withdrawal, there were overall improvements in GFR, serum PO4, and UA.
Renal loss of PO4, UA, protein, and β2-microglobulin reduced over time.
At one year, complete reversal of PRTD was seen in 13 patients (81.2%).
Improvements in PRTD were seen in all but one patient.
Conclusion.
One year after nucleotide analogue withdrawal, PRTD was resolved in most patients.
Changes in TmPO4/GFR, urinary protein, and β2-microglobulin indicate that urinary biomarkers may represent an early sign of PRTD recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sobhonslidsuk, Abhasnee& Numthavaj, Pawin& Wanichanuwat, Jirachaya& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. 2017. Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sobhonslidsuk, Abhasnee…[et al.]. Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sobhonslidsuk, Abhasnee& Numthavaj, Pawin& Wanichanuwat, Jirachaya& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر