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Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B
Joint Authors
Roytrakul, Sittiruk
Jittorntam, Paisan
Petraksa, Supanna
Sobhonslidsuk, Abhasnee
Wanichanuwat, Jirachaya
Numthavaj, Pawin
Sophonsritsuk, Areepan
Pugasub, Alongkorn
Kongsomgan, Anucha
Phakdeekitcharoen, Bunyong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
Proximal renal tubular dysfunction (PRTD) is an infrequent complication after nucleotide analogue therapy.
We evaluated the outcomes of PRTD and nephrotoxicity after nucleotide analogue withdrawal in chronic hepatitis B (CHB).
Methods.
A longitudinal follow-up study was performed in patients with PRTD after nucleotide analogue discontinuation.
Serum and urine were collected at baseline and every 3 months for one year.
The fractional excretion of phosphate (PO4), uric acid (UA), and potassium and tubular maximal reabsorption rate of PO4 to glomerular filtration rate (TmPO4/GFR) were calculated.
Renal losses were defined based on the criteria of substance losses.
Subclinical PRTD and overt PRTD were diagnosed when 2 and ≥3 criteria were identified.
Results.
Eight subclinical and eight overt PRTD patients were enrolled.
After nucleotide analogue withdrawal, there were overall improvements in GFR, serum PO4, and UA.
Renal loss of PO4, UA, protein, and β2-microglobulin reduced over time.
At one year, complete reversal of PRTD was seen in 13 patients (81.2%).
Improvements in PRTD were seen in all but one patient.
Conclusion.
One year after nucleotide analogue withdrawal, PRTD was resolved in most patients.
Changes in TmPO4/GFR, urinary protein, and β2-microglobulin indicate that urinary biomarkers may represent an early sign of PRTD recovery.
American Psychological Association (APA)
Sobhonslidsuk, Abhasnee& Numthavaj, Pawin& Wanichanuwat, Jirachaya& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. 2017. Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136985
Modern Language Association (MLA)
Sobhonslidsuk, Abhasnee…[et al.]. Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136985
American Medical Association (AMA)
Sobhonslidsuk, Abhasnee& Numthavaj, Pawin& Wanichanuwat, Jirachaya& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136985