Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics
المؤلفون المشاركون
Wang, He-Qing
Yang, Hang
Tang, Qian
Gong, Yi-Chen
Fu, Yuan-Hao
Wan, Feng
Yang, Bo
Guo, Rui
Zhong, Yong-Liang
Zhu, Jun-Ming
Zhang, Zhe
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Acute aortic dissection (AAD) is an emergent vascular disease.
Currently, its diagnosis depends on clinical and radiological investigations but lacking of serum biomarkers.
In this study, we aimed to identify potential serum biomarkers for AAD using label-free proteomics approach.
A total of 90 serum samples were collected from three groups: patients with acute aortic dissection (AAD, n=30), patients with acute myocardial infarction (AMI, n=30), and healthy controls (n=30), and the first four samples from each group were selected for label-free proteomics analysis.
Using label-free approach, a total of 22 differentially expressed proteins were identified in the serum samples of the AAD group, of which 15 were upregulated and 7 were downregulated as compared to the AMI and healthy control groups.
The most prominent increased protein was vinculin, which was selected to validate in total samples.
The level of vinculin was significantly elevated in AAD patients (15.8 ng/ml, IQR: 9.3-19.9 ng/ml) than that in AMI patients (8.6 ng/ml, IQR:5.3-11.4 ng/ml) and healthy volunteers (5.3 ng/ml, IQR:2.8-7.6 ng/ml), P<0.0001.
Furthermore, the concentration of vinculin both increased in type A and B dissection.
At the early stage of AAD, vinculin maintained a high level to 48 hours compared with that of AMI.
Our study demonstrated that vinculin may play a role in the early diagnosis of AAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, He-Qing& Yang, Hang& Tang, Qian& Gong, Yi-Chen& Fu, Yuan-Hao& Wan, Feng…[et al.]. 2020. Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, He-Qing…[et al.]. Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, He-Qing& Yang, Hang& Tang, Qian& Gong, Yi-Chen& Fu, Yuan-Hao& Wan, Feng…[et al.]. Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر