Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation
المؤلفون المشاركون
Tian, Xiaopeng
Zhao, Chunhong
Guo, Jinbo
Xie, Shurui
Yin, Fengrong
Huo, Xiaoxia
Zhang, Xiaolan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The sympathetic nervous system (SNS) is responsible for hepatic stellate cells (HSCs) activation and the accumulation of collagen that occurs in hepatic fibrogenesis.
Carvedilol has been widely used for the complication of hepatic cirrhosis in the clinic.
Furthermore, it has powerful antioxidant properties.
We assessed the potential antifibrotic effects of carvedilol and the underlying mechanisms that may further enhance its clinical benefits.
Methods.
Using a bile duct ligation rat model of hepatic fibrosis, we studied the effects of carvedilol on the fibrosis, collagen deposition, and oxidative stress based on histology, immunohistochemistry, western blot, and RT-PCR analyses.
Results.
Carvedilol attenuated liver fibrosis, as evidenced by reduced hydroxyproline content and the accumulation of collagen, downregulated TIMP-1 and TIMP-2, and upregulated MMP-13.
MMP-2 was an exception, which was decreased after carvedilol treatment for 2 weeks and upregulated after carvedilol treatment for 4 weeks.
Carvedilol reduced the activation of HSCs, decreased the induction of collagen, transforming growth factor-β1, and MDA content, and strengthened the SOD activity.
The antifibrotic effects were augmented as dosages increased.
Conclusions.
The study indicates that carvedilol attenuated hepatic fibrosis in a dose-dependent manner.
It can decrease collagen accumulation and HSCs activation by the amelioration of oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Xiaopeng& Zhao, Chunhong& Guo, Jinbo& Xie, Shurui& Yin, Fengrong& Huo, Xiaoxia…[et al.]. 2017. Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Xiaopeng…[et al.]. Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Xiaopeng& Zhao, Chunhong& Guo, Jinbo& Xie, Shurui& Yin, Fengrong& Huo, Xiaoxia…[et al.]. Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر