Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation
Joint Authors
Tian, Xiaopeng
Zhao, Chunhong
Guo, Jinbo
Xie, Shurui
Yin, Fengrong
Huo, Xiaoxia
Zhang, Xiaolan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The sympathetic nervous system (SNS) is responsible for hepatic stellate cells (HSCs) activation and the accumulation of collagen that occurs in hepatic fibrogenesis.
Carvedilol has been widely used for the complication of hepatic cirrhosis in the clinic.
Furthermore, it has powerful antioxidant properties.
We assessed the potential antifibrotic effects of carvedilol and the underlying mechanisms that may further enhance its clinical benefits.
Methods.
Using a bile duct ligation rat model of hepatic fibrosis, we studied the effects of carvedilol on the fibrosis, collagen deposition, and oxidative stress based on histology, immunohistochemistry, western blot, and RT-PCR analyses.
Results.
Carvedilol attenuated liver fibrosis, as evidenced by reduced hydroxyproline content and the accumulation of collagen, downregulated TIMP-1 and TIMP-2, and upregulated MMP-13.
MMP-2 was an exception, which was decreased after carvedilol treatment for 2 weeks and upregulated after carvedilol treatment for 4 weeks.
Carvedilol reduced the activation of HSCs, decreased the induction of collagen, transforming growth factor-β1, and MDA content, and strengthened the SOD activity.
The antifibrotic effects were augmented as dosages increased.
Conclusions.
The study indicates that carvedilol attenuated hepatic fibrosis in a dose-dependent manner.
It can decrease collagen accumulation and HSCs activation by the amelioration of oxidative stress.
American Psychological Association (APA)
Tian, Xiaopeng& Zhao, Chunhong& Guo, Jinbo& Xie, Shurui& Yin, Fengrong& Huo, Xiaoxia…[et al.]. 2017. Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137182
Modern Language Association (MLA)
Tian, Xiaopeng…[et al.]. Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137182
American Medical Association (AMA)
Tian, Xiaopeng& Zhao, Chunhong& Guo, Jinbo& Xie, Shurui& Yin, Fengrong& Huo, Xiaoxia…[et al.]. Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137182