Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes
المؤلفون المشاركون
Yoon, Yohan
Lee, Soomin
Lee, Heeyoung
Kim, Sejeong
Lee, Jeeyeon
Ha, Jimyeong
Choi, Yukyung
Oh, Hyemin
Kim, Yujin
Lee, Yewon
Choi, Kyoung-Hee
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study investigated if intestinal Clostridioides difficile (CD) causes liver injury.
Four-week-old male C3H/HeN mice were treated with phosphate-buffered solution (control), CD, diethylnitrosamine (DEN) to induce liver injury with PBS (DEN+PBS), and DEN with CD (DEN+CD) for nine weeks.
After sacrifice, livers and mesenteric lymph nodes (MLNs) were removed and bacterial translocation, transcriptomes, and proteins were analysed.
CD was found in 20% of MLNs from the control and DEN+PBS groups, in 30% of MLNs from the CD group, and in 75% of MLNs from the DEN+CD groups, which had injured livers.
Also, CD was detected in 50% of the livers in the DEN+CD group with CD-positive MLNs.
Elevated IL-1β, HB-EGF, EGFR, TGF-α, PCNA, DES, HMGB1, and CRP expressions were observed in the CD and DEN+CD groups as compared to the control and DEN+PBS groups.
Protein levels of IL-6 and HMGB1 were higher in the CD and DEN+CD groups than in the control and DEN+PBS groups.
These results indicate that intestinal CD can initiate and aggravate liver injury, and the mechanism of pathogenesis for liver injury should be investigated in further studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Soomin& Lee, Heeyoung& Kim, Sejeong& Lee, Jeeyeon& Ha, Jimyeong& Choi, Yukyung…[et al.]. 2020. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Soomin…[et al.]. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Soomin& Lee, Heeyoung& Kim, Sejeong& Lee, Jeeyeon& Ha, Jimyeong& Choi, Yukyung…[et al.]. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر