Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes
Joint Authors
Yoon, Yohan
Lee, Soomin
Lee, Heeyoung
Kim, Sejeong
Lee, Jeeyeon
Ha, Jimyeong
Choi, Yukyung
Oh, Hyemin
Kim, Yujin
Lee, Yewon
Choi, Kyoung-Hee
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study investigated if intestinal Clostridioides difficile (CD) causes liver injury.
Four-week-old male C3H/HeN mice were treated with phosphate-buffered solution (control), CD, diethylnitrosamine (DEN) to induce liver injury with PBS (DEN+PBS), and DEN with CD (DEN+CD) for nine weeks.
After sacrifice, livers and mesenteric lymph nodes (MLNs) were removed and bacterial translocation, transcriptomes, and proteins were analysed.
CD was found in 20% of MLNs from the control and DEN+PBS groups, in 30% of MLNs from the CD group, and in 75% of MLNs from the DEN+CD groups, which had injured livers.
Also, CD was detected in 50% of the livers in the DEN+CD group with CD-positive MLNs.
Elevated IL-1β, HB-EGF, EGFR, TGF-α, PCNA, DES, HMGB1, and CRP expressions were observed in the CD and DEN+CD groups as compared to the control and DEN+PBS groups.
Protein levels of IL-6 and HMGB1 were higher in the CD and DEN+CD groups than in the control and DEN+PBS groups.
These results indicate that intestinal CD can initiate and aggravate liver injury, and the mechanism of pathogenesis for liver injury should be investigated in further studies.
American Psychological Association (APA)
Lee, Soomin& Lee, Heeyoung& Kim, Sejeong& Lee, Jeeyeon& Ha, Jimyeong& Choi, Yukyung…[et al.]. 2020. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137250
Modern Language Association (MLA)
Lee, Soomin…[et al.]. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137250
American Medical Association (AMA)
Lee, Soomin& Lee, Heeyoung& Kim, Sejeong& Lee, Jeeyeon& Ha, Jimyeong& Choi, Yukyung…[et al.]. Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137250