Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma
المؤلفون المشاركون
He, Yi
Li, Lingling
Zhou, Haiting
Hu, Guoqing
Wu, Cheng
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Lung adenocarcinoma (LUAD) is a major pathological type of lung cancer.
Understanding the mechanism of LUAD at the molecular level is important for a clinical decision.
In this study, we use bioinformatic analysis to explore the prognostic value of P4HA1 in lung adenocarcinoma (LUAD) and the relationship with prognosis and tumor-infiltrating immune cells (TIICs).
The results showed that the expression of P4HA1 was significantly higher in tumor tissues than in normal tissues for LUAD patients.
Upregulated P4HA1 was related to stage and T classification.
Kaplan-Meier analysis indicated that upregulation of P4HA1 was significantly related to worse overall survival (OS).
Univariate and multivariate Cox analysis indicated P4HA1 remained to be an independent prognostic factor.
GSEA showed that several cancer-related and immune-related signaling pathways exhibited prominently differential enrichment in P4HA1-high expression phenotype.
In addition, the expression of P4HA1 was significantly correlated with proportion of several TIICs, particularly B cells and CD4+ T cells.
In conclusion, our study confirmed that P4HA1 is a promising biomarker of poor prognosis and relates to immune infiltrates in LUAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Haiting& He, Yi& Li, Lingling& Wu, Cheng& Hu, Guoqing. 2020. Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Haiting…[et al.]. Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1137325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Haiting& He, Yi& Li, Lingling& Wu, Cheng& Hu, Guoqing. Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر