Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma
Joint Authors
He, Yi
Li, Lingling
Zhou, Haiting
Hu, Guoqing
Wu, Cheng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Lung adenocarcinoma (LUAD) is a major pathological type of lung cancer.
Understanding the mechanism of LUAD at the molecular level is important for a clinical decision.
In this study, we use bioinformatic analysis to explore the prognostic value of P4HA1 in lung adenocarcinoma (LUAD) and the relationship with prognosis and tumor-infiltrating immune cells (TIICs).
The results showed that the expression of P4HA1 was significantly higher in tumor tissues than in normal tissues for LUAD patients.
Upregulated P4HA1 was related to stage and T classification.
Kaplan-Meier analysis indicated that upregulation of P4HA1 was significantly related to worse overall survival (OS).
Univariate and multivariate Cox analysis indicated P4HA1 remained to be an independent prognostic factor.
GSEA showed that several cancer-related and immune-related signaling pathways exhibited prominently differential enrichment in P4HA1-high expression phenotype.
In addition, the expression of P4HA1 was significantly correlated with proportion of several TIICs, particularly B cells and CD4+ T cells.
In conclusion, our study confirmed that P4HA1 is a promising biomarker of poor prognosis and relates to immune infiltrates in LUAD.
American Psychological Association (APA)
Zhou, Haiting& He, Yi& Li, Lingling& Wu, Cheng& Hu, Guoqing. 2020. Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137325
Modern Language Association (MLA)
Zhou, Haiting…[et al.]. Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1137325
American Medical Association (AMA)
Zhou, Haiting& He, Yi& Li, Lingling& Wu, Cheng& Hu, Guoqing. Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137325