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Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway
المؤلفون المشاركون
Zhang, Xincai
Chen, Jinqin
Wang, Shixun
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Atherosclerosis is an important pathological condition which is accompanied by a vascular smooth muscle cell (VSMC) phenotype switch toward a synthetic phenotype.
As an acute-phase protein, Serum Amyloid A (SAA) is thought to have a close relationship to atherosclerosis development.
However, no study has investigated the direct effect of SAA on the VSMC phenotype switch, as well as the underlying mechanisms.
The purpose of our study was to explore the effect of SAA on the VSMC phenotype switch and the potential mechanisms involved.
In our study, we found that SAA induced the VSMC phenotype switch which reduced expression of the smooth muscle cell (SMC) marker and enhanced expression of the matrix synthesis related marker.
The proliferative ability of VSMCs was also increased by SAA treatment.
Furthermore, our research found that SAA activated the ERK1/2 and p38 MAPK signaling pathways.
Finally, by applying the ERK1/2 and p38 inhibitors, U0126 and SB203580, we demonstrated that the SAA-induced VSMC phenotype switch was p38-dependent.
Taken together, these results indicated that SAA may play an important role in promoting the VSMC phenotype switch through the p38 MAPK signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xincai& Chen, Jinqin& Wang, Shixun. 2017. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xincai…[et al.]. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xincai& Chen, Jinqin& Wang, Shixun. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137365
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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