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Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway
Joint Authors
Zhang, Xincai
Chen, Jinqin
Wang, Shixun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Atherosclerosis is an important pathological condition which is accompanied by a vascular smooth muscle cell (VSMC) phenotype switch toward a synthetic phenotype.
As an acute-phase protein, Serum Amyloid A (SAA) is thought to have a close relationship to atherosclerosis development.
However, no study has investigated the direct effect of SAA on the VSMC phenotype switch, as well as the underlying mechanisms.
The purpose of our study was to explore the effect of SAA on the VSMC phenotype switch and the potential mechanisms involved.
In our study, we found that SAA induced the VSMC phenotype switch which reduced expression of the smooth muscle cell (SMC) marker and enhanced expression of the matrix synthesis related marker.
The proliferative ability of VSMCs was also increased by SAA treatment.
Furthermore, our research found that SAA activated the ERK1/2 and p38 MAPK signaling pathways.
Finally, by applying the ERK1/2 and p38 inhibitors, U0126 and SB203580, we demonstrated that the SAA-induced VSMC phenotype switch was p38-dependent.
Taken together, these results indicated that SAA may play an important role in promoting the VSMC phenotype switch through the p38 MAPK signaling pathway.
American Psychological Association (APA)
Zhang, Xincai& Chen, Jinqin& Wang, Shixun. 2017. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137365
Modern Language Association (MLA)
Zhang, Xincai…[et al.]. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137365
American Medical Association (AMA)
Zhang, Xincai& Chen, Jinqin& Wang, Shixun. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137365