Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis
المؤلفون المشاركون
Wu, Yun
Li, Chan
Xia, Jianling
Xie, Ke
Zhao, Feng
Li, Tao
Zeng, Ming
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
A meta-analysis was conducted to estimate the impact of connective tissue growth factor (CTGF) on outcomes in patients with digestive system cancers.
Methods.
A systemic literature survey was performed by searching the Cochrane Library and PubMed databases for articles that evaluated the impact of CTGF on outcomes in patients with digestive system cancers.
Hazard ratios and 95% confidence intervals were calculated for prognostic factors, overall and recurrence-free survival using RevMan 5.3 software.
Results.
This meta-analysis was conducted to evaluate a total of 11 studies that included 1730 patients.
The results showed that elevated CTGF expression was significantly correlated with advanced age, larger tumor size, multiple tumors, and vascular invasion.
Subgroup analysis by cancer type revealed increased risk for lymph node metastasis and advanced tumor node metastasis (TNM) stage in gastric cancer, compared with colorectal cancer.
An unfavorable effect of elevated CTGF levels on overall survival was found in patients with hepatocellular carcinoma and patients with gastric cancer, while survival was improved in colorectal cancer patients with high CTGF expression, compared to those with normal levels of CTGF.
Conclusions.
Elevated CTGF expression may be a novel biomarker for disease status and predicted survival outcomes in patients with specific digestive system cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Feng& Li, Chan& Wu, Yun& Xia, Jianling& Zeng, Ming& Li, Tao…[et al.]. 2020. Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Feng…[et al.]. Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Feng& Li, Chan& Wu, Yun& Xia, Jianling& Zeng, Ming& Li, Tao…[et al.]. Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر