Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population

المؤلفون المشاركون

Yu, Xiangyuan
Qiu, Moqin
Yu, Hongping
Liu, Yingchun
Zhou, Zihan
Jiang, Yanji
Lin, Qiuling
Huo, Rongrui
Liang, Xiumei
Zhou, Xianguo

المصدر

BioMed Research International

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-02-08

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الملخص EN

Damage-specific DNA-binding protein 2 (DDB2) is a DNA repair protein mainly involved in nucleotide excision repair, which plays a pivotal role in maintaining genomic stability.

In this study, we evaluated the association of single-nucleotide polymorphism (SNP) rs1050244 in miRNA target site of DDB2 gene with risk of hepatocellular carcinoma (HCC) among 1073 HCC patients and 1119 cancer-free controls in a southern Chinese population.

Our results showed that no statistically significant association was found between DDB2 rs1050244 and HCC risk.

In further analysis stratified by age, sex, smoking, alcohol drinking, and HBV infection status, we found that individuals carrying the CT/TT genotypes of SNP rs1050244 had a significantly decreased risk of HCC compared with those with the CC genotype among non-HBV infected population (adjusted OR = 0.31, 95% CI = 0.13–0.72), and a significant interaction was found between this SNP and HBV infection (Pinteraction=0.002).

Our results suggested that the DDB2 rs1050244 C>T polymorphism was associated with the decreased risk of HCC among non-HBV infected population.

Further studies with larger sample sizes are needed to validate our findings.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Qiu, Moqin& Liu, Yingchun& Zhou, Zihan& Jiang, Yanji& Lin, Qiuling& Huo, Rongrui…[et al.]. 2020. Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1137501

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Qiu, Moqin…[et al.]. Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1137501

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Qiu, Moqin& Liu, Yingchun& Zhou, Zihan& Jiang, Yanji& Lin, Qiuling& Huo, Rongrui…[et al.]. Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1137501

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1137501