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Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population
Joint Authors
Yu, Xiangyuan
Qiu, Moqin
Yu, Hongping
Liu, Yingchun
Zhou, Zihan
Jiang, Yanji
Lin, Qiuling
Huo, Rongrui
Liang, Xiumei
Zhou, Xianguo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Damage-specific DNA-binding protein 2 (DDB2) is a DNA repair protein mainly involved in nucleotide excision repair, which plays a pivotal role in maintaining genomic stability.
In this study, we evaluated the association of single-nucleotide polymorphism (SNP) rs1050244 in miRNA target site of DDB2 gene with risk of hepatocellular carcinoma (HCC) among 1073 HCC patients and 1119 cancer-free controls in a southern Chinese population.
Our results showed that no statistically significant association was found between DDB2 rs1050244 and HCC risk.
In further analysis stratified by age, sex, smoking, alcohol drinking, and HBV infection status, we found that individuals carrying the CT/TT genotypes of SNP rs1050244 had a significantly decreased risk of HCC compared with those with the CC genotype among non-HBV infected population (adjusted OR = 0.31, 95% CI = 0.13–0.72), and a significant interaction was found between this SNP and HBV infection (Pinteraction=0.002).
Our results suggested that the DDB2 rs1050244 C>T polymorphism was associated with the decreased risk of HCC among non-HBV infected population.
Further studies with larger sample sizes are needed to validate our findings.
American Psychological Association (APA)
Qiu, Moqin& Liu, Yingchun& Zhou, Zihan& Jiang, Yanji& Lin, Qiuling& Huo, Rongrui…[et al.]. 2020. Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1137501
Modern Language Association (MLA)
Qiu, Moqin…[et al.]. Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1137501
American Medical Association (AMA)
Qiu, Moqin& Liu, Yingchun& Zhou, Zihan& Jiang, Yanji& Lin, Qiuling& Huo, Rongrui…[et al.]. Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1137501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137501