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The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis
المؤلفون المشاركون
Bao, Mei-hua
Li, Jian-Ming
Tang, Liang
Wang, Yan
Chen, Yiwei
Chen, Lianghui
Zheng, Shui
Xiang, Ju
Luo, Huaiqing
Li, Yungui
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The serotonin receptor gene (5-HT2A) has been reported to be a susceptible factor in behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD).
However, previous results were conflicting.
We aim to investigate the association of 5-HT2A T102C with BPSD in AD using a meta-analysis.
Studies were collected using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), and Embase.
Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess associations.
Nine studies with 1899 AD patients with/without BPSD were included in this meta-analysis.
The 102C and CC genotypes were associated with psychosis in AD (102C: p<0.00001, OR [95% CI] = 3.19 [2.12–4.79]; CC: p<0.00001, OR [95% CI] = 7.24 [3.60–14.59]).
The TT genotype was significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD (hallucinations: p=0.001, OR [95% CI] = 0.52 [0.36–0.77]; aberrant motor behavior: p=0.03, OR [95% CI] = 0.58 [0.35–0.95]; and psychosis: p=0.002, OR [95% CI] = 0.34 [0.17–0.67]).
No association was observed between T102C alleles or genotypes and delusions, agitation/aggression, depression, and apathy (p>0.05).
Thus, the 5HT2A T102C might be a susceptible factor for hallucinations, aberrant motor behavior, and psychosis in AD.
The potential mechanism of this polymorphism in BPSD in AD requires further exploration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Liang& Wang, Yan& Chen, Yiwei& Chen, Lianghui& Zheng, Shui& Bao, Mei-hua…[et al.]. 2017. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137559
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Liang…[et al.]. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1137559
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Liang& Wang, Yan& Chen, Yiwei& Chen, Lianghui& Zheng, Shui& Bao, Mei-hua…[et al.]. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137559
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137559
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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