The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis
Joint Authors
Bao, Mei-hua
Li, Jian-Ming
Tang, Liang
Wang, Yan
Chen, Yiwei
Chen, Lianghui
Zheng, Shui
Xiang, Ju
Luo, Huaiqing
Li, Yungui
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The serotonin receptor gene (5-HT2A) has been reported to be a susceptible factor in behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD).
However, previous results were conflicting.
We aim to investigate the association of 5-HT2A T102C with BPSD in AD using a meta-analysis.
Studies were collected using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), and Embase.
Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess associations.
Nine studies with 1899 AD patients with/without BPSD were included in this meta-analysis.
The 102C and CC genotypes were associated with psychosis in AD (102C: p<0.00001, OR [95% CI] = 3.19 [2.12–4.79]; CC: p<0.00001, OR [95% CI] = 7.24 [3.60–14.59]).
The TT genotype was significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD (hallucinations: p=0.001, OR [95% CI] = 0.52 [0.36–0.77]; aberrant motor behavior: p=0.03, OR [95% CI] = 0.58 [0.35–0.95]; and psychosis: p=0.002, OR [95% CI] = 0.34 [0.17–0.67]).
No association was observed between T102C alleles or genotypes and delusions, agitation/aggression, depression, and apathy (p>0.05).
Thus, the 5HT2A T102C might be a susceptible factor for hallucinations, aberrant motor behavior, and psychosis in AD.
The potential mechanism of this polymorphism in BPSD in AD requires further exploration.
American Psychological Association (APA)
Tang, Liang& Wang, Yan& Chen, Yiwei& Chen, Lianghui& Zheng, Shui& Bao, Mei-hua…[et al.]. 2017. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137559
Modern Language Association (MLA)
Tang, Liang…[et al.]. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1137559
American Medical Association (AMA)
Tang, Liang& Wang, Yan& Chen, Yiwei& Chen, Lianghui& Zheng, Shui& Bao, Mei-hua…[et al.]. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137559