Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates
المؤلفون المشاركون
Yokota, Shin-ichi
Ohkoshi, Yasuo
Sato, Toyotaka
Suzuki, Yuuki
Yamamoto, Soh
Shiraishi, Tsukasa
Ogasawara, Noriko
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In recent years, multidrug resistance of Escherichia coli has become a serious problem.
However, resistance to fosfomycin (FOM) has been low.
We screened E.
coli clinical isolates with reduced susceptibility to FOM and characterized molecular mechanisms of resistance and reduced susceptibility of these strains.
Ten strains showing reduced FOM susceptibility (MIC ≥ 8 μg/mL) in 211 clinical isolates were found and examined.
Acquisition of genes encoding FOM-modifying enzyme genes (fos genes) and mutations in murA that underlie high resistance to FOM were not observed.
We examined ability of FOM incorporation via glucose-6-phosphate (G6P) transporter and sn-glycerol-3-phosphate transporter.
In ten strains, nine showed lack of growth on M9 minimum salt agar supplemented with G6P.
Eight of the ten strains showed fluctuated induction by G6P of uhpT that encodes G6P transporter expression.
Nucleotide sequences of the uhpT, uhpA, glpT, ptsI, and cyaA shared several deletions and amino acid mutations in the nine strains with lack of growth on G6P-supplemented M9 agar.
In conclusion, reduction of uhpT function is largely responsible for the reduced sensitivity to FOM in clinical isolates that have not acquired FOM-modifying genes or mutations in murA.
However, there are a few strains whose mechanisms of reduced susceptibility to FOM are still unclear.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohkoshi, Yasuo& Sato, Toyotaka& Suzuki, Yuuki& Yamamoto, Soh& Shiraishi, Tsukasa& Ogasawara, Noriko…[et al.]. 2017. Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137645
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohkoshi, Yasuo…[et al.]. Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137645
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohkoshi, Yasuo& Sato, Toyotaka& Suzuki, Yuuki& Yamamoto, Soh& Shiraishi, Tsukasa& Ogasawara, Noriko…[et al.]. Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137645
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137645
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر