Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives
المؤلفون المشاركون
Di Maio, Massimo
Zichi, Clizia
Tucci, Marcello
Leone, Gianmarco
Buttigliero, Consuelo
Vignani, Francesca
Pignataro, Daniele
Scagliotti, Giorgio V.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In recent years, immunotherapy has produced encouraging results in a rapidly increasing number of solid tumors.
The responsiveness of bladder cancer to immunotherapy was first established in nonmuscle invasive disease in 1976 with intravesical instillations of bacillus Calmette-Guérin (BCG).
Very recently immune checkpoint inhibitors demonstrated good activity and significant efficacy in metastatic disease.
In particular the best results were obtained with programmed death-ligand-1 (PD-L1) and programmed death-1 (PD-1) inhibitors, but many other immune checkpoint inhibitors, including anti-cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibodies, are currently under investigation in several trials.
Simultaneously other therapeutic strategies which recruit an adaptive immune response against tumoral antigens or employ externally manipulated tumor infiltrating lymphocytes might change the natural history of bladder cancer in the near future.
This review describes the rationale for the use of immunotherapy in bladder cancer and discusses recent and ongoing clinical trials with checkpoint inhibitors and other novel immunotherapy agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zichi, Clizia& Tucci, Marcello& Leone, Gianmarco& Buttigliero, Consuelo& Vignani, Francesca& Pignataro, Daniele…[et al.]. 2017. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1137680
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zichi, Clizia…[et al.]. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1137680
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zichi, Clizia& Tucci, Marcello& Leone, Gianmarco& Buttigliero, Consuelo& Vignani, Francesca& Pignataro, Daniele…[et al.]. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1137680
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137680
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر