![](/images/graphics-bg.png)
Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives
Joint Authors
Di Maio, Massimo
Zichi, Clizia
Tucci, Marcello
Leone, Gianmarco
Buttigliero, Consuelo
Vignani, Francesca
Pignataro, Daniele
Scagliotti, Giorgio V.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In recent years, immunotherapy has produced encouraging results in a rapidly increasing number of solid tumors.
The responsiveness of bladder cancer to immunotherapy was first established in nonmuscle invasive disease in 1976 with intravesical instillations of bacillus Calmette-Guérin (BCG).
Very recently immune checkpoint inhibitors demonstrated good activity and significant efficacy in metastatic disease.
In particular the best results were obtained with programmed death-ligand-1 (PD-L1) and programmed death-1 (PD-1) inhibitors, but many other immune checkpoint inhibitors, including anti-cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibodies, are currently under investigation in several trials.
Simultaneously other therapeutic strategies which recruit an adaptive immune response against tumoral antigens or employ externally manipulated tumor infiltrating lymphocytes might change the natural history of bladder cancer in the near future.
This review describes the rationale for the use of immunotherapy in bladder cancer and discusses recent and ongoing clinical trials with checkpoint inhibitors and other novel immunotherapy agents.
American Psychological Association (APA)
Zichi, Clizia& Tucci, Marcello& Leone, Gianmarco& Buttigliero, Consuelo& Vignani, Francesca& Pignataro, Daniele…[et al.]. 2017. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1137680
Modern Language Association (MLA)
Zichi, Clizia…[et al.]. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1137680
American Medical Association (AMA)
Zichi, Clizia& Tucci, Marcello& Leone, Gianmarco& Buttigliero, Consuelo& Vignani, Francesca& Pignataro, Daniele…[et al.]. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1137680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137680