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Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities
المؤلفون المشاركون
Alarifi, Saud
Surendrakumar, Radhakrishnan
Idhayadhulla, Akbar
Ahamed, Nazeer Anis
Sathish Kumar, Chidambaram
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Copper nanoparticles (Cu-Nps) are one of the promising materials for the advancement of nanoscience and technology.
In this work, we synthesized telmisartan copper nanoparticles and 2-pyrimidinamines via Biginelli reaction using telmisartan copper nanoparticles (Cu-Nps) as a reusable catalyst.
The synthesis of 2-pyrimidinamine derivatives (1a-c) was achieved in water and under solvent-free condition (Green chemistry approach).
Synthesis of 2-pyrimidinamine with telmisartan copper nanoparticle (Cu-Nps–Pyr) unexpected product was also isolated from synthesis of 2-pyrimidinamine preparation.
Antioxidant and cytotoxic activities were carried out both in 2-pyrimidinamine (1a-1c) and 2-pyrimidinamine with telmisartan copper nanoparticles (Cu-Nps–Pyr).
The synthesized 2-pyrimidinamine derivatives (1a-c) were characterized from FT-IR, 1H and 13C NMR spectroscopy, mass and elemental analyses.
The synthesized telmisartan copper nanoparticles (Cu-Nps) were characterized from UV spectroscopy, XRD, SEM, EDX, AFM (atomic force microscopy), profile, waviness, and roughness analyses.
Antioxidant activity was screened based on ABTS⋅+ radical scavenging and linoleic acid peroxidation performance.
Cu-Nps–Pyr-1b showed substantial antioxidant (97.2%) activity against ABTS⋅+ assay and 91.2% activity against AAPH assays compared with Trolox.
Cytotoxicity was evaluated using HepG2, HeLa, and MCF-7 cell lines, the Cu-Nps–Pyr-1a is high in toxicities (GI50=0.01 μm) against the HeLa cancel cell line compared with doxorubicin.
The developed copper NPs with 2-pyrimidinamine (Cu-Nps–Pyr) could provide promising advances as antioxidant activities; this nanocomposition could be considered an anticancer treatment in future investigations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Surendrakumar, Radhakrishnan& Idhayadhulla, Akbar& Alarifi, Saud& Ahamed, Nazeer Anis& Sathish Kumar, Chidambaram. 2020. Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Surendrakumar, Radhakrishnan…[et al.]. Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Surendrakumar, Radhakrishnan& Idhayadhulla, Akbar& Alarifi, Saud& Ahamed, Nazeer Anis& Sathish Kumar, Chidambaram. Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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