Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities
Joint Authors
Alarifi, Saud
Surendrakumar, Radhakrishnan
Idhayadhulla, Akbar
Ahamed, Nazeer Anis
Sathish Kumar, Chidambaram
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Copper nanoparticles (Cu-Nps) are one of the promising materials for the advancement of nanoscience and technology.
In this work, we synthesized telmisartan copper nanoparticles and 2-pyrimidinamines via Biginelli reaction using telmisartan copper nanoparticles (Cu-Nps) as a reusable catalyst.
The synthesis of 2-pyrimidinamine derivatives (1a-c) was achieved in water and under solvent-free condition (Green chemistry approach).
Synthesis of 2-pyrimidinamine with telmisartan copper nanoparticle (Cu-Nps–Pyr) unexpected product was also isolated from synthesis of 2-pyrimidinamine preparation.
Antioxidant and cytotoxic activities were carried out both in 2-pyrimidinamine (1a-1c) and 2-pyrimidinamine with telmisartan copper nanoparticles (Cu-Nps–Pyr).
The synthesized 2-pyrimidinamine derivatives (1a-c) were characterized from FT-IR, 1H and 13C NMR spectroscopy, mass and elemental analyses.
The synthesized telmisartan copper nanoparticles (Cu-Nps) were characterized from UV spectroscopy, XRD, SEM, EDX, AFM (atomic force microscopy), profile, waviness, and roughness analyses.
Antioxidant activity was screened based on ABTS⋅+ radical scavenging and linoleic acid peroxidation performance.
Cu-Nps–Pyr-1b showed substantial antioxidant (97.2%) activity against ABTS⋅+ assay and 91.2% activity against AAPH assays compared with Trolox.
Cytotoxicity was evaluated using HepG2, HeLa, and MCF-7 cell lines, the Cu-Nps–Pyr-1a is high in toxicities (GI50=0.01 μm) against the HeLa cancel cell line compared with doxorubicin.
The developed copper NPs with 2-pyrimidinamine (Cu-Nps–Pyr) could provide promising advances as antioxidant activities; this nanocomposition could be considered an anticancer treatment in future investigations.
American Psychological Association (APA)
Surendrakumar, Radhakrishnan& Idhayadhulla, Akbar& Alarifi, Saud& Ahamed, Nazeer Anis& Sathish Kumar, Chidambaram. 2020. Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137802
Modern Language Association (MLA)
Surendrakumar, Radhakrishnan…[et al.]. Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137802
American Medical Association (AMA)
Surendrakumar, Radhakrishnan& Idhayadhulla, Akbar& Alarifi, Saud& Ahamed, Nazeer Anis& Sathish Kumar, Chidambaram. Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137802