Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis
المؤلفون المشاركون
Xu, Ji-Xiong
Tang, Yun-Liang
Yu, Jiao
Liu, Jian-Ying
Zhu, Ling-Yan
Li, Yu
Wang, Jiao
Zeng, Xiang-Xia
Hu, Kai-Xiang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Studies have suggested that metformin can potentially decrease the incidence of cancer and improve survival outcomes.
However, the association between metformin use and the incidence and survival of endometrial cancer (EC) remains controversial.
So, a meta-analysis was performed.
An electronic search was conducted using PubMed, EMBASE, and Web of Science.
The outcome measures were relative risks (RRs) or hazard ratios (HRs) with 95% confidence intervals (CIs) comparing the EC incidence and survival in patients treated with and without metformin.
Eleven studies involving 766,926 participants were included in this study.
In the pooled analysis of five studies which evaluated the association of metformin use with the incidence of EC, we found that metformin use was associated with a 13% reduction in EC risk among patients with diabetes (RR = 0.87, 95% CI: 0.80–0.95; p=0.006).
In the pooled analysis of six retrospective cohort studies evaluating the effect of metformin on the survival of EC patients, we found that, relative to nonuse, metformin use significantly improved the survival of EC patients (HR = 0.63, 95% CI: 0.45–0.87; p=0.006).
This study showed that metformin use was significantly associated with a decreased incidence of EC in diabetes and a favorable survival outcome of EC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Yun-Liang& Zhu, Ling-Yan& Li, Yu& Yu, Jiao& Wang, Jiao& Zeng, Xiang-Xia…[et al.]. 2017. Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137836
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Yun-Liang…[et al.]. Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137836
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Yun-Liang& Zhu, Ling-Yan& Li, Yu& Yu, Jiao& Wang, Jiao& Zeng, Xiang-Xia…[et al.]. Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137836
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137836
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر