Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis
Joint Authors
Xu, Ji-Xiong
Tang, Yun-Liang
Yu, Jiao
Liu, Jian-Ying
Zhu, Ling-Yan
Li, Yu
Wang, Jiao
Zeng, Xiang-Xia
Hu, Kai-Xiang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Studies have suggested that metformin can potentially decrease the incidence of cancer and improve survival outcomes.
However, the association between metformin use and the incidence and survival of endometrial cancer (EC) remains controversial.
So, a meta-analysis was performed.
An electronic search was conducted using PubMed, EMBASE, and Web of Science.
The outcome measures were relative risks (RRs) or hazard ratios (HRs) with 95% confidence intervals (CIs) comparing the EC incidence and survival in patients treated with and without metformin.
Eleven studies involving 766,926 participants were included in this study.
In the pooled analysis of five studies which evaluated the association of metformin use with the incidence of EC, we found that metformin use was associated with a 13% reduction in EC risk among patients with diabetes (RR = 0.87, 95% CI: 0.80–0.95; p=0.006).
In the pooled analysis of six retrospective cohort studies evaluating the effect of metformin on the survival of EC patients, we found that, relative to nonuse, metformin use significantly improved the survival of EC patients (HR = 0.63, 95% CI: 0.45–0.87; p=0.006).
This study showed that metformin use was significantly associated with a decreased incidence of EC in diabetes and a favorable survival outcome of EC patients.
American Psychological Association (APA)
Tang, Yun-Liang& Zhu, Ling-Yan& Li, Yu& Yu, Jiao& Wang, Jiao& Zeng, Xiang-Xia…[et al.]. 2017. Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137836
Modern Language Association (MLA)
Tang, Yun-Liang…[et al.]. Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137836
American Medical Association (AMA)
Tang, Yun-Liang& Zhu, Ling-Yan& Li, Yu& Yu, Jiao& Wang, Jiao& Zeng, Xiang-Xia…[et al.]. Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137836